The Incidence Of Alzheimer s Disease Essay - 1380 Words

Etiology The incidence of Alzheimer’s disease is 36 million people worldwide as of 2010, making it the most common cause of senile dementia. 1This number is expected to nearly double, to 65.7 million by 2030.1AD is accompanied by pathological features consistent with brain atrophy and neural cell death. 1The inflammatory response of the brain, that is commonly found in AD, is linked to several factors. 1Amyloid-B, inflammatory cytokines, and sphingolipids are some of the known factors associated with AD. 1Uncontrolled inflammation, from ongoing or chronic complement activation is theorized to impact Alzheimer’s disease, among other diseases. 2 Recent GWAS shows strong evidence that complement receptor CR1 is linked to the development of AD, although the mechanistic basis for the CR1 risk remains largely unknown.2 Pathogenesis Emerging evidence demonstrates neuroinflammation as a crucial pathophysiology of AD, specifically impacted by microglia and astroglia. 3 The microglia are distributed evenly across the brain and are activated by protein aggregation and neuronal cell death. 3 Specifically related to AD, the two chief proteins involved are amyloid-B and tau.3 An accumulation of microglia around amyloid-B plaques has been documented in post-mortem human brains and in animal models with AD.3 Research has yet to clearly determine if microglial activation plays a beneficial or detrimental role in the progression of AD..3 Some reports suggest that microglia are attracted toShow MoreRelatedA Research Study On Alzheimer s Disease Research Studies757 Words   |  4 PagesProposed approaches to conducting the research How should the research (involving the prospect of increasing the participation of African Americans in Alzheimer s disease research studies) be conducted? 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According to the Alzheimer’s Association, in 1906, German physician Alois Alzheimer was â€Å"one of the first to link the symptoms of the disease to the microscopic brain changes.† In 1910, Emil Kraepelin, a German ps ychiatrist who worked with Dr. Alzheimer, first names Alzheimer s Disease in the eighth editionRead MoreCoffee Benefits1019 Words   |  5 PagesBenefits [edit] Reduced risk of Alzheimer s disease Several studies comparing moderate coffee drinkers (about 2 cups a day) with light coffee drinkers (less than one cup a day) found that those who drank more coffee were significantly less likely to develop Alzheimer s disease later in life. [2][3] [edit] Reduced risk of gallstone disease Drinking caffeinated coffee has been correlated with a lower incidence of gallstones and gallbladder disease in both men[4] and women[5] in two studies performedRead MoreDementia With Lewy Bodies ( Dlb )1473 Words   |  6 Pages(DLB) is a type of dementia that shares symptoms with both Alzheimer s disease and Parkinson s disease. It may account for around 10 per cent of all cases of dementia (Alzheimer’s Society, 2016). Lewy refers to the inflammation or neuro-inflammation of the brain (Surendranathan et al, 2015). Both Parkinson s disease and dementia with Lewy bodies are age-related diseases, although onset before age 65 years is not uncommon and both diseases are more common in men than in women (Walker et al, 2015)